The quality and the purity of the dialysis fluid are of major concern in renal replacement therapies, as large volumes of dialysis fluid come into contact with the patient’s bloodstream during each treatment.
In treatments, such as ONLINE Hemodiafiltration, in which large fluid volumes are exchanged, the quality and purity of the substitution fluid are of even greater importance.

Bacterial endotoxins and other microbial contaminations present in dialysis fluid may elicit undesirable acute reactions and influence long-term patient outcomes. In order to avoid endotoxin-related complications in dialysis, the usage of ultra pure dialysis fluid is strongly recommended.

The routine production of ultra pure dialysis fluid and substitution fluid relies on the implementation of ultrafilters – such as DIASAFEplus – within the fluid pathway of the dialysis machine.

• DIASAFEplus – Dialysis fluid filter with Fresenius Polysulfone based membrane fibres. Endotoxins and other microbial products are retained through size-exclusion principles and adsorption during cross-flow filtration.

• Ultra pure dialysis fluid – Dialysis fluid having a high degree of purity with endotoxins below 0.03 IU/mL.

• The routine application of ultra pure dialysis fluid helps to reduce dialysis-related inflammation. Moreover, it improves the control of anaemia, making it an important cornerstone of Cardioprotective Hemodialysis.